Epilepsy and Aluminium #epilessia e #alluminio, trovate all'interno dei post link di traduzione #epilessia #alluminio

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Posted on 18/6/2019, 12:05

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There is a long (and perhaps regrettable) history of the injection of aluminium salts into brain tissue in animal (including primates) models of human epilepsy. With this in mind, it may be surprising that our recent research (www.mdpi.com/1660-4601/16/12/2129) is the first to measure and identify aluminium in human epilepsy. We present a case report of another victim of the Camelford water-poisoning incident (https://www.hippocraticpost.com/neurology/...minium-scandal/) where an exposed individual developed adult onset epilepsy and died following an epileptic seizure. The hippocampus was the main target for aluminium where it had accumulated to pathologically significant concentrations. Aluminium-specific fluorescence showed that aluminium was loaded into glial cells as well as being associated with deposits of neuronal/cellular debris. The hippocampus is an important target in epilepsy and our observation of the selective accumulation of aluminium in this region of the brain must raise the possibility that aluminium plays a role in the disease. Previous research implicating aluminium in human epilepsy would include our work on aluminium in brain tissue in autism (https://www.hippocraticpost.com/infection-...ium-and-autism/), research linking Dravet’s disease with aluminium adjuvants in vaccines (https://www.hippocraticpost.com/infection-...nium-adjuvants/) and early research identifying high blood aluminium in epilepsy. Future research should investigate human exposure to aluminium and epilepsy and specifically post mortem if brain aluminium is consistently elevated in the disease.

Regarding the aluminium poisoning at Camelford in 1998 we have now investigated three donated brains from exposed individuals and we have measured elevated aluminium in all three. The brain tissues in these individuals were all characterised by unusual neuronal pathologies associated with cerebral amyloid angiopathy (https://www.hippocraticpost.com/neurology/...minium-scandal/), sporadic Alzheimer’s disease (https://www.hippocraticpost.com/neurology/...minium-scandal/), and herein, adult onset epilepsy. It is surely time that a thorough investigation of health effects emanating from Camelford is initiated.
www.hippocraticpost.com/neurology/epilepsy-and-aluminium/

ATTENZIONE ARTICOLO TRADOTTO CON https://www.translatetheweb.com/?from=&to=...nd-aluminium%2F
Epilessia e alluminio
C'è una lunga (e forse deplorevole) storia dell'iniezione di sali di alluminio nel tessuto cerebrale nei modelli animali (compresi i primati) dell'epilessia umana. Con questo in mente, può sorprendere che la nostra recente ricerca (www.mdpi.com/1660-4601/16/12/2129) sia la prima a misurare e identificare l'alluminio nell'epilessia umana. Presentiamo un rapporto di caso di un'altra vittima dell'incidente di avvelenamento dell'acqua di Camelford (https://www.hippocraticpost.com/neurology/...minium-scandal/) in cui un individuo esposto adulto insorgere epilessia e morì a seguito di una crisi epilettica. L'ippocampo era il principale obiettivo dell'alluminio dove si era accumulato a concentrazioni patologicamente significative. La fluorescenza specifica dell'alluminio ha mostrato che l'alluminio è stato caricato in cellule gliali, oltre ad essere associato a depositi di detriti neuronali/cellulari. L'ippocampo è un obiettivo importante nell'epilessia e la nostra osservazione dell'accumulo selettivo di alluminio in questa regione del cervello deve aumentare la possibilità che l'alluminio svolga un ruolo nella malattia. Ricerca precedente che implica di alluminio nell'epilessia umana includerebbe il nostro lavoro sull'alluminio nel tessuto cerebrale nella ricerca di autismo (https://www.hippocraticpost.com/infection-...ium-and-autism/), che collega la malattia di Dravet con coadiuvanti di alluminio nei vaccini (https://www.hippocraticpost.com/infection-...nium-adjuvants/) e presto ricerca identificando in alluminio alta anima nell'epilessia. La ricerca futura dovrebbe indagare esposizione umana a alluminio ed epilessia e specificamente post mortem se alluminio cervello è costantemente elevata nella malattia.

Per quanto riguarda l'avvelenamento da alluminio a Camelford nel 1998, abbiamo ora studiato tre cervelli donati da individui esposti e abbiamo misurato l'alluminio elevato in tutti e tre. I tessuti cerebrali in questi individui erano tutti caratterizzati da patologie neuronali insolite associate all'angiopatia amiloide cerebrale (https://www.hippocraticpost.com/neurology/...minium-scandal/), sporadiche Malattia di Alzheimer (https://www.hippocraticpost.com/neurology/...minium-scandal/), e qui, epilessia di esordio adulto. È sicuramente giunto il momento di avviare un'indagine approfondita degli effetti sulla salute emanata da Camelford.
https://www.translatetheweb.com/?from=&to=...nd-aluminium%2F

Professor Chris Exley
Professor in Bioinorganic Chemistry Keele University
Honorary Professor, UHI Millennium Institute
Group Leader - Bioinorganic Chemistry Laboratory at Keele

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Posted on 18/6/2019, 12:11

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Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford
Matthew Mold 1, Jason Cottle 2 and Christopher Exley 1,*
1
The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
2
School of Medicine, David Weatherly Building, Keele University, Staffordshire ST5 5BG, UK
*
Author to whom correspondence should be addressed.

Int. J. Environ. Res. Public Health 2019, 16(12), 2129; https://doi.org/10.3390/ijerph16122129

Received: 2 May 2019 / Revised: 14 June 2019 / Accepted: 14 June 2019 / Published: 16 June 2019
Abstract
(1) Introduction: Human exposure to aluminium is a burgeoning problem. In 1988, the population of the Cornish town of Camelford was exposed to exceedingly high levels of aluminium in their potable water supply. Herein we provide evidence that aluminium played a role in the death of a Camelford resident following development of late-onset epilepsy. (2) Case summary: We have measured the aluminium content of brain tissue in this individual and demonstrated significant accumulations of aluminium in the hippocampus (4.35 (2.80) µg/g dry wt.) and the occipital lobe (2.22 (2.23) µg/g dry wt., mean, SD, n = 5), the latter being associated with abnormal calcifications. Aluminium-specific fluorescence microscopy confirmed the presence of aluminium in both of these tissues and made the consistent observation of aluminium-loaded glial cells in close proximity to aluminium-rich cell/neuronal debris. These observations support an inflammatory component in this case of late-onset epilepsy. Congo red failed to identify any amyloid deposits in any tissue while thioflavin S showed extensive extracellular and intracellular tau pathologies. (3) Discussion: We present the first data showing aluminium in brain tissue in epilepsy and suggest, in light of complementary evidence from scientific literature, the first evidence that aluminium played a role in the advent of this case of late-onset adult epilepsy. View Full-Text

www.mdpi.com/1660-4601/16/12/2129

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Posted on 18/12/2019, 18:14

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J Biol Inorg Chem. 2019 Dec;24(8):1279-1282. doi: 10.1007/s00775-019-01710-0. Epub 2019 Aug 29.
Aluminium in human brain tissue: how much is too much?
Exley C1, Mold MJ2.
Author information
1The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK. [email protected] Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK.
Erratum in
Correction to: Aluminium in human brain tissue: how much is too much? [J Biol Inorg Chem. 2019]
Abstract
A burgeoning body of research confirms and affirms the presence of aluminium in human brain tissue. Recently, the first data on aluminium content of brain tissue from donors with diagnoses of familial Alzheimer's disease, autism spectrum disorder, multiple sclerosis and epilepsy have been published. Quantitative data are supported by aluminium-specific fluorescence microscopy identifying the locations of aluminium in human brain tissue. The challenge in the future will be to confirm or refute the role played by brain aluminium intoxication in human neurodegenerative disease.
www.ncbi.nlm.nih.gov/pubmed/31468176
https://link.springer.com/article/10.1007%...775-019-01710-0
ATTENZIONE ARTICOLO TRADOTTO CONhttps://www.translatetheweb.com/?ref=TVert...pubmed/31468176
Alluminio nel tessuto cerebrale umano: quanto è troppo?
Exley C1, Stampo MJ2.
Informazioni sull'autore
1Il Birchall Centre, I Laboratori Lennard-Jones, Keele University, Staffordshire, ST5 5BG, Regno Unito. [email protected] Birchall Centre, I Laboratori Lennard-Jones, Keele University, Staffordshire, ST5 5BG, Regno Unito.
Erratum in
Correzione a: Alluminio nel tessuto cerebrale umano: quanto è troppo? [J Biol Inorg Chem. 2019]
astratto
Un fiorente corpus di ricerche conferma e afferma la presenza di alluminio nel tessuto cerebrale umano. Recentemente, sono stati pubblicati i primi dati sul contenuto di alluminio del tessuto cerebrale dei donatori con diagnosi di malattia familiare dell'Alzheimer, disturbo dello spettro autistico, sclerosi multipla ed epilessia. I dati quantitativi sono supportati dalla microscopia a fluorescenza specifica sull'alluminio che identifica le posizioni dell'alluminio nel tessuto cerebrale umano. La sfida in futuro sarà quella di confermare o confutare il ruolo svolto dall'intossicazione da alluminio cerebrale nelle malattie neurodegenerative umane.
https://www.translatetheweb.com/?ref=TVert...pubmed/31468176

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Posted on 25/2/2020, 19:17

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Neuro Endocrinol Lett. 2013;34(6):504-7.
Iron and aluminum in Alzheimer's disease.
Di Lorenzo F1, Di Lorenzo B2.
Author information
1"Ambulatorio Privato di Scienze Mediche", Valenzano, Bari, Italy. [email protected]"Ambulatorio Privato di Scienze Mediche", Valenzano, Bari, Italy.
Abstract
In this case presentation, a woman with high serum levels of aluminum was treated with chelation therapy with deferoxamine and ascorbic acid. This patient was initially bedridden and the clinical situation was complicated by epileptic seizures. After the chelation therapy, the clinical condition was ameliorated and the therapy continued without the correlation to aluminum serum levels. The role of metals in neurodegenerative disorders and the correlation between iron metabolism and amyloid beta peptide are described. This case suggests chelation therapy could represent a promising therapeutic option for this dramatic disease.
www.ncbi.nlm.nih.gov/pubmed/24378455

ATTENZIONE ARTICOLO TRADOTTO CONhttps://www.translatetheweb.com/?ref=TVert...bmed%2F24378455
In questo caso, una donna con alti livelli sierici di alluminio è stata trattata con la terapia chelante con deferoxamina e acido ascorbico. Questa paziente è stata inizialmente costretta a letto e la situazione clinica è stata complicata da crisi epilettiche. Dopo la terapia chelante, la condizione clinica è stata migliorata e la terapia è continuata senza la correlazione con i livelli sierici di alluminio. Il ruolo dei metalli nei disturbi neurodegenerativi e la correlazione tra il metabolismo del ferro e il beta peptide amiloide sono descritti. Questo caso suggerisce che la terapia chelante potrebbe rappresentare un'opzione terapeutica promettente per questa drammatica malattia.
https://www.translatetheweb.com/?ref=TVert...bmed%2F24378455

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